Naason Science offers tools to study CNS Diseases in rodents and larger animals. From in vitro systems to large and small animal in vivo models Naason Science provides a tool box of state-of-the-art technologies that allow for rapid and effective testing of preclinical drug candidates.
Naason Science scientists have expertise in all major CNS diseases and tools to develop novel therapies for rare and orphan diseases.
Alpha-synuclein (α-syn) protofibrils facilitate the formation of protein aggregates in the brain Parkinson´s disease has been extensively modelled in rodents. However, the ability to reliably recreate the protein misfolding, inflammatory responses, psychiatric and motor symptoms of PD have been hard to recreate. This model facilitates a quicker induction of α-syn aggregates in the brain of the rat and is analogous to that which occurs in the human.
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R6/2 mouse, which expresses mutant human exon 1 HTT was the first genetically modified mouse line produced and has been the most extensively studied and utilized mouse model of HD.
Naason Science has completed validation of R6/2 mouse line for the study of HD; the model paradigm has a complete functional and behavioral battery, imaging (MRI/MRS) and histological and molecular analysis of various regions of brain.
Naason Science model assays:
Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, causing loss of muscle control. Naason Science has validated the transgenic SOD1 model of ALS. SOD1 mice exhibit a phenotype similar to ALS in humans and are the most widely used animal model in ALS Drug Discovery Studies.
Histology: NMJ innervation
MDX mouse (on a C57BL/10ScSn-Dmdmdx/J) is a the most highly used model for the study of DMD.
Naason Science has completed validation of it’s MDX mouse model for the study of DMD, the model paradigm has a complete functional and behavioral battery as well as imaging (MRI) and histological analysis of limb muscles, diaphragm and heart. In addition, gene expression rounds out the paradigm.