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Advanced Parkinson´s disease modelling α-syn-pff injection
Alpha-synuclein (α-syn) protofibrils facilitate the formation of protein aggregates in the brain Parkinson´s disease has been extensively modelled in rodents. However, the ability to reliably recreate the protein misfolding, inflammatory responses, psychiatric and motor symptoms of PD have been hard to recreate. This model facilitates a quicker induction of α-syn aggregates in the brain of the rat and is analogous to that which occurs in the human.
Home Cage / Group Housed Analysis Behavioural Phenotypes
- Total Moving Distance (mm)
- Total Moving Time (s)
- Separation/Isolation Distance (mm)
- Isolated Time (s)
- Thigmotactic Time (s)
- In Center Zone Time (s)
- Drinking Time (s)
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MPTP Model of Parkinson’s disease
- MPTP administration induces symptoms of Parkinson’s disease by destroying dopaminergic neurons in the substantia nigra of the brain
- The Model is fully validated by Naason Science
- Acute and chronic paradigms are validated and available
- Validated under all administration routes: IP, IT, SC, ICV, IV
- Grip strength, Pole test, and active staining of dopaminergic neurons (Tyrosine hydroxylase)
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R6/2 Transgenic Mouse Model of Huntington´s Disease
R6/2 mouse, which expresses mutant human exon 1 HTT was the first genetically modified mouse line produced and has been the most extensively studied and utilized mouse model of HD.
- Model is fully validated by Naason Science
- Licensed for 3rd party CRO use (KCL)
- 20 years of experience with the R6/2 **
- Validated with all administration routes (IP, PO, SC, IP, IM, ICV, IT)
- Studies of Behavior and Cognition
- Studies of Muscle Function, Motor Activity and Gait
- In-house breeding programs available
Naason Science model assays:
- Grip Strength
- RotaRod
- Home cage rearing
- Home cage locomotor activity
- Imaging (MRI/MRS, PET-SPECT / CT)
- Histology / Stereology
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TG Mouse Model of Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, causing loss of muscle control. Naason Science has validated the transgenic SOD1-G93A Model of ALS. SOD1 mice exhibit a phenotype similar to ALS in humans and are the most widely used animal model in ALS Drug Discovery Studies.
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Naason´s MDX Model of Duchenne Muscular Dystrophy
MDX mouse (on a C57BL/10ScSn-Dmdmdx/J) is a the most highly used model for the study of DMD.
Naason Science has completed validation of it’s MDX mouse model for the study of DMD, the model paradigm has a complete functional and behavioral battery as well as imaging (MRI) and histological analysis of limb muscles, diaphragm and heart. In addition, gene expression rounds out the paradigm.
CNS In Vitro Platform
- Primary Hipp Neurons
- Primary Cortical Neurons
- Primary DA Neurons
- SN4741 DA Neuronal Cell Lines
- In vitro AD, PD, HD
- Oxidative Stress (ROS)
- Mitochondrial Function
- Neuronal Outgrowth
- Cell Death
- High Content Screening
- HTS