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NaIO3-induced dry AMD
Naason Science offers a mouse model of dry AMD induced by NaIO3 injection. This model provides rapid phenotypic changes such as damage of tight junction integrity and thinning of retinal layers that can be assessed by immunohistochemical analyses.
Laser-induced CNV model of wet AMD
Dry AMD can progress to wet AMD when abnormal blood vessels develop underneath the retina. Wet AMD can be induced by photocoagulation of the retina using the 532 nm laser. The choroidal neovascularization (CNV) formed by the laser can be measured in vivo using optical coherence tomography and fluorescein angiography. We also offer immunohistochemical analyses on flatmounts using markers for CNV and subretinal fibrosis, which often accompanies wet AMD.
Two-stage laser-induced Model of Subretinal Fibrosis
In this Model, the 532 nm laser is applied in two stages in the same lesion to produce a more severe phenotype of AMD and to induce subretinal fibrosis. Fibrosis is quantified by immunohistochemical staining after flatmounting. In this Model, the area of fibrosis increases 30 days after the second laser burn, providing a platform to test therapeutic efficacy of compounds.