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Cardiovascular Disease Models
Naason Science offers advanced preclinical models to study cardiovascular diseases such as hypertension, atherosclerosis, heart failure, and ischemia. Using both large and small animal models along with cutting-edge imaging and diagnostics, we simulate key pathological and physiological conditions, enabling robust assessment of disease progression and treatment efficacy.
Complete Atrioventricular Block (CAVB) Model
Naason Science’s Complete Atrioventricular Block (CAVB) model offers a robust, validated platform for studying severe cardiac conduction disorders where the atrial-ventricular electrical signal is fully blocked. This model is designed to closely mimic the pathophysiology seen in human patients, supporting the reliable assessment of therapeutic approaches and device efficacy prior to clinical trials.
Our CAVB model is ideal for testing drugs, cardiac devices like pacemakers, and novel therapies. Utilizing advanced imaging and real-time monitoring, the model enables precise physiological measurements and extended observation periods, enhancing data accuracy and reproducibility. With this model, Naason Science provides a powerful tool for advancing cardiovascular disease research and the development of life-saving treatments.
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Pacemaker-Induced Cardiomyopathy (PICM) Model
Naason Science’s Pacemaker-Induced Cardiomyopathy (PICM) model provides an advanced platform for investigating cardiomyopathy resulting from mechanical and biological mismatch during retrograde conduction in electrically stimulated hearts. This model simulates the effects of long-term pacemaker use, particularly in cases of complete atrioventricular block (CAVB), offering critical insights into disease mechanisms and potential therapeutic approaches.
Our validated PICM model is tailored for preclinical testing of drugs, cardiac devices, and novel treatment methods. Leveraging sophisticated imaging and monitoring techniques, the model supports accurate physiological assessments and extended studies, making it an invaluable tool for cardiovascular research and the development of improved interventions for pacemaker-dependent patients.
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Myocardial Infarction (MI) Model
Naason Science’s Myocardial Infarction (MI) model offers a reliable platform for evaluating drug efficacy in the context of ischemia-reperfusion (I/R) injury, which induces acute myocardial infarction. This model accurately replicates the physiological impact of MI, providing a robust foundation for studying disease mechanisms and testing therapeutic interventions before clinical trials.
Our MI model is particularly suited for assessing cardiovascular drugs, protective agents, and innovative therapies targeting ischemic damage. Utilizing advanced imaging and diagnostic technologies, the model enables precise monitoring of cardiac function and recovery, delivering critical insights for the development of effective treatments for myocardial infarction.
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