PTSD is a serious anxiety disorder that can lead to intense fear and anxiety. Current medication is unspecific and ineffective, with a number of side effects. One limiting factor in the development of treatment for PTSD is the lack of valid, translational models. Naason Science has been developing models of PTSD in the rat and has initiated a development program in a larger animal - the minipig, based on a multi-faceted prolonged stress paradigm, so as to test the efficacy of new compounds.
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Naason Science is part of a consortium for the development of a new potential treatment to reduce fear memory in post-traumatic stress disorder (PTSD). By selectively targeting mGlu7 with NAMs, the brain circuitries involved in fear and anxiety can be precisely modulated, potentially resulting in higher efficacy and fewer side effects.
Please find more information about the project here.