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Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system and cognition. The most obvious symptoms are shaking, rigidity, slowness of movement, and difficulty with walking, which are collectively called "parkinsonism" or a "parkinsonian syndrome". The motor symptoms of the disease come from the build-up of proteins into Lewy bodies and neuronal death in the substantia nigra, which results in not enough dopamine in this region of the brain. More than 6 million people are affected by PD globally. There is no cure for Parkinson's disease.
Parkinson´s disease has been extensively modelled in rodents. However, the ability to reliably recreate the protein misfolding, inflammatory responses, psychiatric and motor symptoms of PD have been hard to recreate. This model facilitates a quicker induction of α-syn aggregates in the brain of the rat and is analogous to that which occurs in the human.
MPTP administration induces symptoms of Parkinson’s disease by destroying dopaminergic neurons in the substantia nigra of the brain
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