Naason Science
Naason Science
  • Home
  • CRO Services
    • Preclinical Research
    • Histology Services
    • CNS Models
    • Pain Models
    • Cardiovascular Models
    • Ophthalmology Models
    • Internal Disease Models
    • Psychiatric Models
    • Bone and Autoimmune
    • Safety and Toxicity
    • In Vitro
  • News
  • Virtual Gallery
  • Investors
  • Contact
  • More
    • Home
    • CRO Services
      • Preclinical Research
      • Histology Services
      • CNS Models
      • Pain Models
      • Cardiovascular Models
      • Ophthalmology Models
      • Internal Disease Models
      • Psychiatric Models
      • Bone and Autoimmune
      • Safety and Toxicity
      • In Vitro
    • News
    • Virtual Gallery
    • Investors
    • Contact
  • Sign In

  • My Account
  • Signed in as:

  • filler@godaddy.com


  • My Account
  • Sign out

Signed in as:

filler@godaddy.com

  • Home
  • CRO Services
    • Preclinical Research
    • Histology Services
    • CNS Models
    • Pain Models
    • Cardiovascular Models
    • Ophthalmology Models
    • Internal Disease Models
    • Psychiatric Models
    • Bone and Autoimmune
    • Safety and Toxicity
    • In Vitro
  • News
  • Virtual Gallery
  • Investors
  • Contact

Account


  • My Account
  • Sign out


  • Sign In
  • My Account

Amyotrophic Lateral Sclerosis (ALS) Models

Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive neurodegenerative disorder that leads to the death of neurons controlling voluntary muscles. Symptoms include muscle stiffness, twitching, and gradual weakness, ultimately causing the loss of critical functions like walking, speaking, and breathing. While most cases (90-95%) have no known cause and are likely influenced by genetic and environmental factors, around 5-10% are inherited.


At Naason Science, our Preclinical Research Models are instrumental in studying ALS pathology and evaluating potential treatments. These models replicate key aspects of ALS, such as motor neuron degeneration and muscle weakness, providing valuable insights into disease progression. By leveraging these models, we aim to advance the understanding of ALS and support the development of therapies that can improve patient outcomes and quality of life.

Transgenic (SOD-1) mouse MODEL

Riluzole is a medication that may slightly extend life expectancy by two to three months, but there is currently no cure for ALS. Some familial cases involve mutations in the copper/zinc superoxide dismutase (SOD-1) gene, and studies using G93A SOD-1 mice have provided insights into the disease's pathology, revealing a correlation between mutant SOD expression and motor neuron degeneration.


Species: Mice

Gene: Male/Female

Disease Relevance: Mutations in superoxide dismutase 1 gene (SOD1) with G93A mutation are linked to amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder predominantly affecting upper and lower motor neurons. Robust muscle weakness can be observed.

back to cns models

For more information please

contact us

© 2017-2025 Naason Science Inc. All rights reserved.

  • Home
  • Preclinical Research
  • News
  • Areas of Expertise
  • Privacy & Terms
  • Contact

Powered by

Welcome to Naason Science website!

Our website uses cookies. By continuing to use this site, you accept our use of cookies.

DeclineAccept