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At Naason Science, we are committed to advancing women's health through the development of high-quality preclinical models. Women's health has historically been underrepresented in research, yet conditions such as endometriosis and polycystic ovary syndrome (PCOS) affect millions worldwide and significantly impact quality of life.
Our dedicated models provide researchers with powerful tools to investigate disease mechanisms and to evaluate new therapeutic approaches. By supporting innovation in this important field, we aim to contribute to better diagnostic options, treatments, and ultimately improved health outcomes for women.
Endometriosis is an estrogen-dependent inflammatory disorder characterized by the presence of endometrial tissue outside the uterine cavity. Patients experience chronic pelvic pain and infertility, with the most likely origin of the tissue deposits (lesions) being endometrial fragments shed at menses. Menstruation is an inflammatory process associated with a dramatic increase in inflammatory mediators and tissue-resident immune cells. The first reported murine model of endometriosis induced lesions by surgical engraftment. This model involves the placement, by suture or adhesion, of uterine tissue into the peritoneal cavity of the same or a recipient mouse. A novel mouse model of Endometriosis is developed that uses syngeneic mouse menstrual donor tissue introduced into the peritoneum of immunocompetent recipient mice.
Study paradigms for examining endometriosis in mice require precision and practice. In general, Naason Science has a 90% success rate in the creation of vascularized endometriomas as well as endometrial tissue. The methodology involves hormonal priming and decidualization in the donor mice and then the correct methodology to introduce donor tissue.
Endometriosis is an estrogen-dependent inflammatory disorder characterized by the presence of endometrial tissue outside the uterine cavity. Patients experience chronic pelvic pain and infertility, with the most likely origin of the tissue deposits (lesions) being endometrial fragments shed at menses.
Naason Science autograft model of endometriosis has an 80 % rate of success in the implantation of autografts from donors to study groups and is confirmed by observation of stromal cells and epithelial cells in donors. The model can be used as a biochemical and histopathological model and also exhibits ongoing pain as well as anxiety and depression.
Intrastudy and study endpoint readouts from the model are:
Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age, characterized by hormonal imbalance, ovarian cysts, and metabolic issues. At Naason Science, we are developing preclinical PCOS models to support research into the pathophysiology of the disorder and to assist in the development of novel therapeutic interventions. These models provide a reliable platform for studying disease mechanisms and evaluating potential treatments aimed at improving metabolic and reproductive health outcomes in women affected by PCOS.
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