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  • Home
  • Research
    • Preclinical Research
    • CNS Models
    • Pain Models
    • Endometriosis Models
    • Oncology Models
    • Ophthalmology Models
    • Orthopedic Models
    • Metabolic Disease Models
    • Psychiatric Models
    • In Vitro
    • Safety & Toxicity Studies
  • News
  • Careers
    • Naason Team
    • Join the team
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Pain Modelling Platform

Naason Science approaches the nonclinical modelling of pain with a combination of classical pain models but also includes end-points that can point toward efficacy studies in the burden of differing types of pain on body systems. Therefore, along with these classical models we also include the ability to examine signs of anxiety and depression in various pain models along with the pain associated with cancers, endometriosis and diseases such as MS and PD.


Naason Neuropathic and Local Pain Models and Areas of Expertise: 

  • Ligation models for pain (Chung and CCI)
  • Visceral pain (Cisplatin and Oxilaplatin induced pain)
  • Post operative pain
  • Trigeminal neuralgia
  • Pain associated with endometriosis  

L5 Spinal Nerve Ligation (Chung Model) for Neuropathic Pain

  • Spinal nerve ligation at level of L5
  • Control compound Gabapentin
  • 8, 14 or 21 day studies


Intrastudy readouts:

  • von Frey for mechanical allodynia
  • Ultrasonic vocalization counts
  • Homecage, group housed, rearing, locomotor activity
  • Homecage social activity for anxiety and depression (social distance)
  • Eating
  • Drinking 
  • Grooming
  • Body Weight
  • Serum inflammary and neuro markers
  • End-point tissue analysis

Ultrasonic Vocalizations Count - Group Housed HomeCage

Bladder pain (cystitis) CCP Model for Abdominal Pain

- Administration of the anticancer agent cyclophosphamide to induce bladder pain  

- Morphine as a benchmark control    


Intrastudy readouts include:  

  • Abdominal von Frey 
  • Ultrasonic vocalization (USV) 
  • Serum biomarkers for inflammation 
  • Home cage, group housed, locomotor and social activity 
  • Home cage rearing, eating, drinking, circadian rhythm, aggression and posture 
  • Home cage distance travelled and velocity 
  • Body Weight   


End of study readouts:  

  • FACS 
  • SPECT 
  • Neuronal and Inflammatory mar

Ultrasonic Vocalizations Count - Group Housed HomeCage

Ultrasonic Vocalizations Count - Group Housed HomeCage 

We have also following Models available

  • CCI-induced NP in rats
  • Chung-induced NP in rats
  • Cisplatin-induced NP
  • Visceral pain model (Cyclophosphamide-induced bladder & hindpaw pain) in rats
  • Chemotherapy (Cisplatin)-induced NP model
  • Chemotherapy (Oxyliplatin)-induced NP model
  • Endometriosis in mice, rats and mini-pigs


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