Pain Modelling Platform

Naason Science approaches the nonclinical modelling of pain with a combination of classical pain models but also includes end-points that can point toward efficacy studies in the burden of differing types of pain on body systems. Therefore, along with these classical models we also include the ability to examine signs of anxiety and depression in various pain models along with the pain associated with cancers, endometriosis and diseases such as MS and PD.

Naason Neuropathic and Local Pain Models and Areas of Expertise:

Ligation models for pain (Chung and CCI)
Visceral pain (Cisplatin and Oxilaplatin induced pain)
Post operative pain
Trigeminal neuralgia
Pain associated with endometriosis

L5 Spinal Nerve Ligation (Chung Model) for Neuropathic Pain

-Spinal nerve ligation at level of L5

-Control compound Gabapentin

-8, 14 or 21 day studies

Intrastudy readouts:

von Frey for mechanical allodynia
Ultrasonic vocalization counts
Homecage, group housed, rearing, locomotor activity
Homecage social activity for anxiety and depression (social distance)
Eating
Drinking
Grooming
Body Weight
Serum inflammary and neuro markers
End-point tissue analysis

Ultrasonic Vocalizations Count - Group Housed HomeCage

Bladder pain (cystitis) CCP Model for Abdominal Pain

- Administration of the anticancer agent cyclophosphamide to induce bladder pain

- Morphine as a benchmark control

Intrastudy readouts include:

Abdominal von Frey
Ultrasonic vocalization (USV)
Serum biomarkers for inflammation
Home cage, group housed, locomotor and social activity
Home cage rearing, eating, drinking, circadian rhythm, aggression and posture
Home cage distance travelled and velocity
Body Weight

End of study readouts:

FACS
SPECT
Neuronal and Inflammatory mar

Ultrasonic Vocalizations Count - Group Housed HomeCage

Pain Modelling Platform

L5 Spinal Nerve Ligation (Chung Model) for Neuropathic Pain

Bladder pain (cystitis) CCP Model for Abdominal Pain

We have also following Models available

For more information please

Pain Modelling Platform

L5 Spinal Nerve Ligation (Chung Model) for Neuropathic Pain

Bladder pain (cystitis) CCP Model for Abdominal Pain

We have also following Models available

For more information please

Welcome to Naason Science website!