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Naason Science approaches the nonclinical modelling of pain with a combination of classical pain models but also includes end-points that can point toward efficacy studies in the burden of differing types of pain on body systems. Therefore, along with these classical models we also include the ability to examine signs of anxiety and depression in various pain models along with the pain associated with cancers, endometriosis and diseases such as MS and PD.
Naason Neuropathic and Local Pain Models and Areas of Expertise:
The chronic constriction injury (CCI) is a partial nerve injury, mostly used in rodents, which is produced by tying several ligatures around a nerve, such that these ligatures slightly constrict the nerve. This induces an incomplete nerve injury, which entails behavioral signs of hyperalgesia in the animals. Partial ligation of the sciatic nerve (pSNL) is a procedure that induces chronic neuropathic pain in mice, characterized by mechanical and thermal hypersensitivity, ongoing pain, and changes in limb temperature, making this model a great fit to study neuropathic pain preclinically.
The SNL (Chung) model is a tool to study pharmacotherapy for chronic neuropathic pain. This model is used to identify experimental compounds with analgesic properties that are palliative for chronic neuropathic pain. The surgical procedure involves ligation of the L5 and L6 spinal nerves to create peripheral pain.
Most people who complete a full course of cisplatin chemotherapy develop a sensory neuropathy (damage to nerves that carry sensation). Symptoms can include tingling in the extremities and numbness.
Cisplatin-induced peripheral neuropathy (CIPN) is a frequent serious dose-dependent adverse event that can determine dosage limitations for cancer treatment. CIPN severity correlates with the amount of platinum detected in sensory neurons of the dorsal root ganglia (DRG).
Rats and mice are the most commonly used animal models used to assess colonic physiology, pathophysiology, and new treatment approaches for visceral pain. This visceral pain pathway is viscerotopically organized into two distinct ascending bundles traveling on either side of the fasciculus gracilis with the visceral afferent information received in the thoracic or the lumbosacral level of the spinal cord, respectively.
Many studies have been performed on cyclophosphamide (CP)-induced hemorrhagic cystitis to assess the protective action of different treatments CP is an antitumoral agent known to produce frequent toxic effects on the bladder wall of treated patients, resulting in hemorrhagic cystitis through its main toxic metabolite.
EthoVision XT is the most widely applied video tracking software that tracks and analyzes the behavior, movement, and activity of any animal. Free Trial What's new. A cost-effective solution for all standard behavioral tests such as the Morris water maze and open field testing.
OXL induces two types of peripheral neuropathy; acute and chronic. The acute oxaliplatin-induced peripheral neuropathy (OXLIPN) may be linked to the rapid chelation of calcium by OXL-induced oxalate and OXL is capable of altering the voltage-gated sodium channels through a pathway involving calcium ions.
In 70% of cases, prolonged exposure to oxaliplatin induces a severe chronic peripheral neuropathy. Some of the chemotherapy and other drugs used to treat cancer can damage peripheral nerves. When this happens it is called chemotherapy-induced peripheral neuropathy (CIPN). This can be a disabling side effect of cancer treatment.
Ultrasonic vocalizations (USVs) occur at frequencies ranging from approximately 20–100 kHz. They are emitted by animals such as bats and rodents, and have been extensively studied in rats and mice. As opposed to sonic vocalizations, ultrasonic vocalizations cannot be detected by the human ear. Young and adult rats emit the so-called 22-kHz USVs in response to a wide series of stimuli they perceive as threatening; therefore 22-kHz USVs are often referred to as “alarm calls”. These vocalizations are characterized by a relatively constant frequency and a long duration (up to seconds).
Endometriosis is an estrogen-dependent inflammatory disorder characterized by the presence of endometrial tissue outside the uterine cavity. Patients experience chronic pelvic pain and infertility, with the most likely origin of the tissue deposits (lesions) being endometrial fragments shed at menses. Menstruation is an inflammatory process associated with a dramatic increase in inflammatory mediators and tissue-resident immune cells. The first reported murine model of endometriosis induced lesions by surgical engraftment. This model involves the placement, by suture or adhesion, of uterine tissue into the peritoneal cavity of the same or a recipient mouse. A novel mouse model of Endometriosis is developed that uses syngeneic mouse menstrual donor tissue introduced into the peritoneum of immunocompetent recipient mice.