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L5 Spinal Nerve Ligation (Chung Model) for Neuropathic Pain
- Spinal nerve ligation at level of L5
- Control compound Gabapentin
- 8, 14 or 21 day studies
Intrastudy readouts:
- von Frey for mechanical allodynia
- Ultrasonic vocalization counts
- Homecage, group housed, rearing, locomotor activity
- Homecage social activity for anxiety and depression (social distance)
- Eating
- Drinking
- Grooming
- Body Weight
- Serum inflammary and neuro markers
- End-point tissue analysis
Ultrasonic Vocalizations Count - Group Housed HomeCage
Bladder pain (cystitis) CCP Model for Abdominal Pain
- Administration of the anticancer agent cyclophosphamide to induce bladder pain
- Morphine as a benchmark control
Intrastudy readouts include:
- Abdominal von Frey
- Ultrasonic vocalization (USV)
- Serum biomarkers for inflammation
- Home cage, group housed, locomotor and social activity
- Home cage rearing, eating, drinking, circadian rhythm, aggression and posture
- Home cage distance travelled and velocity
- Body Weight
End of study readouts:
- FACS
- SPECT
- Neuronal and Inflammatory mar
Ultrasonic Vocalizations Count - Group Housed HomeCage
We have also following Models available
- CCI-induced NP in rats
- Chung-induced NP in rats
- Cisplatin-induced NP
- Visceral pain model (Cyclophosphamide-induced bladder & hindpaw pain) in rats
- Chemotherapy (Cisplatin)-induced NP model
- Chemotherapy (Oxyliplatin)-induced NP model
- Endometriosis in mice, rats and mini-pigs
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