Internal Disease Models

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Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn’s disease, are complex, chronic conditions with unclear origins, affecting millions worldwide. The dextran sulfate sodium (DSS)-induced colitis model is widely used in preclinical research due to its simplicity and close resemblance to human ulcerative colitis. By administering DSS, this model induces inflammation in the colon, replicating key aspects of IBD, including immune response activation, mucosal damage, and ulceration.

Naason Science’s DSS model provides a valuable tool for studying the pathophysiology of colitis and assessing potential therapeutic compounds for treating IBD. With its reliable replication of inflammatory processes, this model aids in the development of treatments aimed at managing symptoms and improving quality of life for patients with chronic colitis.

• Species: Mouse​
• Gene: N/A​
• Modification: DSS​
• Disease Relevance: Ulcerative coitis like symptoms​
• Strain Names: C57BL6

The Common Bile Duct (CBD) and Hepatic Duct (CHD) ligation model is a well-established preclinical model used to study liver injury and biliary diseases, including fibrosis, cirrhosis, and cholestasis. By surgically ligating the bile ducts in rats, this model effectively induces cholestatic liver injury, simulating conditions of bile accumulation, liver inflammation, and progressive fibrosis, closely resembling aspects of human biliary disease.

Our assessments in this model include body and organ weight measurements (liver, kidney, spleen) to track systemic and organ-specific impacts. Comprehensive liver necropsy and histopathology identify necrosis, fibrosis, and inflammatory changes within the liver. Additional evaluations include a full hematology panel and serum biochemistry to monitor liver function and systemic responses to bile duct obstruction.

Naason Science’s CBD and CHD ligation model provides valuable insights for testing potential therapies aimed at reducing fibrosis, inflammation, and other liver pathologies associated with cholestatic diseases, supporting the development of treatments to improve liver health and function.

The High-Fat Diet (HFD)-Induced MASH (Metabolic Associated Steatohepatitis) model in mice provides a robust platform for studying the progression of fatty liver disease to its more severe form, MASH. By replicating dietary and metabolic factors, this model closely mirrors human pathology, including liver inflammation, fibrosis, and lipid accumulation.

Naason Science’s HFD-Induced MASH model is ideal for evaluating therapeutic compounds, exploring metabolic pathways, and identifying potential biomarkers for early diagnosis and treatment. With detailed assessments such as histopathology, liver function tests, and gene expression analysis, this model supports the development of targeted therapies to address liver-related metabolic diseases effectively.

The Ischemia-Reperfusion (IR)-Induced Acute Kidney Injury (AKI) model is a well-established preclinical tool for studying kidney damage caused by the temporary restriction and restoration of blood flow. This model replicates the key features of human AKI, including inflammation, oxidative stress, and renal cell injury, providing a reliable platform for investigating the underlying mechanisms of kidney damage.

At Naason Science, our IR-induced AKI model enables researchers to evaluate the efficacy of potential therapeutics, assess renal recovery, and explore strategies to mitigate damage caused by ischemia-reperfusion injury. Detailed analyses, including renal function tests, histopathology, and biomarker evaluations, support the development of targeted therapies to improve kidney health and patient outcomes.