Preclinical Models of Disease

We offer an integrated approach to preclinical studies with all aspects and facilities available on site. Models and studies are designed in collaboration with the sponsor and specifically tuned to the clients needs.

The Naason process starts from an in-depth knowledge of the demands of global pharmaceutical development. It involves combining superior knowledge of biological systems and system dynamics with the latest preclinical disease models, highlighting the comparative and translatable aspects and using this data to highlight the way forward for a particular drug or a drug development platform.

Safety and Toxicity Studies

Rodents and larger species (rabbits, pigs, dogs and NHP) all aspects of non-clinical safety and toxicity can be studied.

Genotox, ecotox, immuno-tox, reprotox, carcinogenic toxicity
Species: Rat, Mouse, Guinea Pig, Pig, Rabbit, Canine and NHP

Single dose toxicity test
Dose Range Finding(DRF)
Maximum Tolerated Dose(MTD) test
Repeat dosing toxicity test
Local sensitization tests (scheduled)
Skin sensitization tests (rabbit) ocular sensitization tests (rabbit)
Other toxicity test
Antigen test, skin sensation test, photon toxicity test

Functional Efficacy and Metabolic Tests in multiple species

Effects on memory & cognition
Liver & hepatic metabolism
Body fat changes
Menopausal symptoms
Ocular effects
Immune system
Blood glucose regulation
Bone, joint and muscular
Prostate
Fatigue/lethargy
Dermal effects
Blood pressure regulation
Calcium intake
Urinary tract, renal function
Digestion
Improvement of neutral fat
Erectile dysfunction