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What is endometriosis?
Endometriosis is an often painful disorder in which tissue similar to the tissue that normally lines the inside of your uterus — the endometrium — grows outside your uterus. Endometriosis most commonly involves your ovaries, fallopian tubes and the tissue lining your pelvis. Rarely, endometrial-like tissue may be found beyond the area where pelvic organs are located.
With endometriosis, the endometrial-like tissue acts as endometrial tissue would — it thickens, breaks down and bleeds with each menstrual cycle. But because this tissue has no way to exit your body, it becomes trapped. When endometriosis involves the ovaries, cysts called endometriomas may form. Surrounding tissue can become irritated, eventually developing scar tissue and adhesions — bands of fibrous tissue that can cause pelvic tissues and organs to stick to each other.
Endometriosis can cause pain — sometimes severe — especially during menstrual periods. Fertility problems also may develop. Fortunately, effective treatments are available.
Learn More about our Preclinical Endometriosis Model
Naason Science Endometriosis Model in Rats
Endometriosis is an estrogen-dependent inflammatory disorder characterized by the presence of endometrial tissue outside the uterine cavity. Patients experience chronic pelvic pain and infertility, with the most likely origin of the tissue deposits (lesions) being endometrial fragments shed at menses.
Naason Science autograft model of endometriosis has an 80 % rate of success in the implantation of autografts from donors to study groups and is confirmed by observation of stromal cells and epithelial cells in donors. The model can be used as a biochemical and histopathological model and also exhibits ongoing pain as well as anxiety and depression.
Intrastudy and study endpoint readouts from the model are:
- Inflammatory markers (TNF-alpha, IL1-Beta, Total antioxidant activity of test article (TAC)) etc. Continual core temperature in group housed rats
- Social distancing in the home cage
- Home cage locomotor activity in group housed conditions
- Animal postural changes Home cage rearing
- Ultrasonic vocalization (USV)
- Mechanical allodynia (von Frey) – including bladder
- Histopathlogical scoring (including mean volumes of inplants)
- Raloxifene as a control to gauge pelvic pain from endometriosis
- Plasma haematology and PCR
Cyst formation
We are AAALAC-Accredited
We are proud to report that we are an Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) accredited facility. AAALAC International is a nonprofit organization that promotes the humane treatment of laboratory animals.