Metabolic Disease Models

Diet-Induced NASH (Nonalcoholic Steatohepatitis) in Mice

Common Bile Duct Ligation Model (CBD) and Hepatic Duct Ligation Model (CHD)

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Diet-Induced NASH in Mice

The model is a fast start, low cost model that will allow researches to examine drug effect in this most extreme form of NAFLD.


  • Body weight
  • Liver weight / body weight ratio
  • Liver morphological analysis
  • Clinical pathology
  • Fibrosis-related gene expression level
  • Histopathology analysis
  • Magnetic Resonance Imaging

Histopathology analysis
Histopathology analysis

Common Bile (CBD) and Hepatic Duct Ligation Model (CHD)

 

Bile duct ligation in rat

  • Body weight
  • Organ weight (liver, kidney, spleen)
  • Liver necropsy
  • Full hematology panel
  • Serum biochemistry
  • Histopathology for necrosis or fibrosis inflammation

Organ weight
Organ weight