Typical Endometriosis Study Paradigm in Mice
Study paradigms for examining endometriosis in mice require precision and practice. In general, Naason Science has a 90% success rate in the creation of vascularized endometriomas as well as endometrial tissue. The methodology involves hormonal priming and decidualization in the donor mice and then the correct methodology to introduce donor tissue.
- The model can be used to examine treatments and therapies aimed at reduction of the size and number of endometriomas
- the composition of endometriomas and endometrial tissue
- inflammatory markers abdominal and peripheral pain responses
- anxiety/depression and other discrete behaviours in home-cage, group housed conditions
- various molecular markers of inflammation and cytokine response
