Endometriosis Modelling Platform

Endometriosis is an estrogen-dependent inflammatory disorder characterized by the presence of endometrial tissue outside the uterine cavity. Patients experience chronic pelvic pain and infertility, with the most likely origin of the tissue deposits (lesions) being endometrial fragments shed at menses. 

Naason Science autograft model of endometriosis has an 80 % rate of success in the implantation of autografts from donors to study groups and is confirmed by observation of stromal cells and epithelial cells in donors. The model can be used as a biochemical and histopathological model and also exhibits ongoing pain as well as anxiety and depression. 

Intrastudy and study endpoint readouts from the model are:

• Inflammatory markers (TNF-alpha, IL1-Beta, Total antioxidant activity of test article (TAC)) etc.
• Continual core temperature in group housed rats
• Social distancing in the home cage
• Home cage locomotor activity in group housed conditions
• Animal postural changes
• Home cage rearing
• Ultrasonic vocalization (USV)
• Mechanical allodynia (von Frey) – including bladder
• Histopathlogical scoring (including mean volumes of inplants)
• Raloxifene as a control to gauge pelvic pain from endometriosis
• Plasma haematology and PCR