Study paradigms for examining endometriosis in mice require precision and practice. In general, Naason Science has a 90% success rate in the creation of vascularized endometriomas as well as endometrial tissue. The methodology involves hormonal priming and decidualization in the donor mice and then the correct methodology to introduce donor tissue.
Endometriosis is an estrogen-dependent inflammatory disorder characterized by the presence of endometrial tissue outside the uterine cavity. Patients experience chronic pelvic pain and infertility, with the most likely origin of the tissue deposits (lesions) being endometrial fragments shed at menses.
Naason Science autograft model of endometriosis has an 80 % rate of success in the implantation of autografts from donors to study groups and is confirmed by observation of stromal cells and epithelial cells in donors. The model can be used as a biochemical and histopathological model and also exhibits ongoing pain as well as anxiety and depression.
Intrastudy and study endpoint readouts from the model are:
A typical paradigm for endometriosis in Naason’s laboratories: