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DSS-induced Colitis Model
Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn’s disease, are complex, chronic conditions with unclear origins, affecting millions worldwide. The dextran sulfate sodium (DSS)-induced colitis model is widely used in preclinical research due to its simplicity and close resemblance to human ulcerative colitis. By administering DSS, this model induces inflammation in the colon, replicating key aspects of IBD, including immune response activation, mucosal damage, and ulceration.
Naason Science’s DSS model provides a valuable tool for studying the pathophysiology of colitis and assessing potential therapeutic compounds for treating IBD. With its reliable replication of inflammatory processes, this model aids in the development of treatments aimed at managing symptoms and improving quality of life for patients with chronic colitis.
Diet-Induced NASH in Mice
The Diet-Induced Non-Alcoholic Steatohepatitis (NASH) model is an efficient and cost-effective approach for studying the progression of non-alcoholic fatty liver disease (NAFLD) to its most severe form, NASH. This model enables researchers to examine the effects of therapeutic compounds on key disease markers, simulating the metabolic and histological changes observed in human NASH.
In this model, assessments include body weight, liver-to-body weight ratio, and detailed liver morphological analysis to evaluate the extent of steatosis, inflammation, and fibrosis. Advanced clinical pathology parameters and fibrosis-related gene expression analysis offer insights into disease progression at the molecular level. Histopathology further characterizes tissue damage, while non-invasive Magnetic Resonance Imaging (MRI) provides visual evidence of liver changes, enhancing the understanding of drug efficacy over time.
Naason Science’s Diet-Induced NASH model provides a powerful tool for preclinical research, supporting the development of treatments aimed at reducing liver inflammation, fibrosis, and other pathological effects associated with NASH.
Common Bile (CBD) and Hepatic Duct Ligation Model (CHD)
The Common Bile Duct (CBD) and Hepatic Duct (CHD) ligation model is a well-established preclinical model used to study liver injury and biliary diseases, including fibrosis, cirrhosis, and cholestasis. By surgically ligating the bile ducts in rats, this model effectively induces cholestatic liver injury, simulating conditions of bile accumulation, liver inflammation, and progressive fibrosis, closely resembling aspects of human biliary disease.
Our assessments in this model include body and organ weight measurements (liver, kidney, spleen) to track systemic and organ-specific impacts. Comprehensive liver necropsy and histopathology identify necrosis, fibrosis, and inflammatory changes within the liver. Additional evaluations include a full hematology panel and serum biochemistry to monitor liver function and systemic responses to bile duct obstruction.
Naason Science’s CBD and CHD ligation model provides valuable insights for testing potential therapies aimed at reducing fibrosis, inflammation, and other liver pathologies associated with cholestatic diseases, supporting the development of treatments to improve liver health and function.
